Systematic Review of Chiropractic Care for Non-musculoskeletal Conditions

doi: ten.1186/s12998-021-00362-nine.

The global height on the efficacy and effectiveness of spinal manipulative therapy for the prevention and treatment of non-musculoskeletal disorders: a systematic review of the literature

Pierre Côté ^{1 2 3 4} , Iben Axén ^{vii 8} , Charlotte Leboeuf-Yde ^nine , Melissa Corso ^{10 11} , Heather Shearer ^{eleven 12} , Jessica Wong ^{ten 11 13} , Andrée-Anne Marchand ¹⁴ , J David Cassidy ¹³ , Simon French ¹⁵ , Gregory N Kawchuk ¹⁶ , Silvano Mior ^{11 17} , Erik Poulsen ⁵ , John Srbely ^eighteen , Carlo Ammendolia ^{12 19} , Marc-André Blanchette ¹⁴ , Jason W Busse ²⁰ , André Bussières ^{14 21} , Carolina Cancelliere ^{x 11} , Henrik Wulff Christensen ⁶ , Diana De Carvalho ²² , Katie De Luca ^fifteen , Alister Du Rose ²³ , Andreas Eklund ⁷ , Roger Engel ¹⁵ , Guillaume Goncalves ²⁴ , Jeffrey Hebert ²⁵ , Cesar A Hincapié ²⁶ , Maria Hondras ²⁷ , Amanda Kimpton ²⁸ , Henrik Hein Lauridsen ⁵ , Stanley Innes ²⁹ , Anne-Laure Meyer ²⁴ , David Newell ^thirty , Søren O'Neill ^{ix 31} , Isabelle Pagé ¹⁴ , Steven Passmore ³² , Stephen G Perle ³³ , Jeffrey Quon ³⁴ , Mana Rezai ¹¹ , Maja Stupar ¹⁷ , Michael Swain ¹⁵ , Andrew Vitiello ³⁵ , Kenneth Weber ³⁶ , Kenneth J Young ³⁷ , Hainan Yu ^{x 11}

Affiliations

• PMID: 33596925
• PMCID: PMC7890602
• DOI: 10.1186/s12998-021-00362-9

Costless PMC article

The global pinnacle on the efficacy and effectiveness of spinal manipulative therapy for the prevention and handling of non-musculoskeletal disorders: a systematic review of the literature

Pierre Côté  et al. Chiropr Man Therap. 2021 .

Gratis PMC article

Erratum in

• Correction to: The global summit on the efficacy and effectiveness of spinal manipulative therapy for the prevention and treatment of non-musculoskeletal disorders: a systematic review of the literature.

  Côté P, Hartvigsen J, Axén I, Leboeuf-Yde C, Corso M, Shearer H, Wong J, Marchand AA, Cassidy JD, French Due south, Kawchuk GN, Mior S, Poulsen E, Srbely J, Ammendolia C, Blanchette MA, Busse JW, Bussières A, Cancelliere C, Christensen HW, De Carvalho D, De Luca One thousand, Du Rose A, Eklund A, Engel R, Goncalves 1000, Hebert J, Hincapié CA, Hondras M, Kimpton A, Lauridsen HH, Innes S, Meyer AL, Newell D, O'Neill S, Pagé I, Passmore S, Perle SM, Quon J, Rezai Thou, Stupar M, Beau Thousand, Vitiello A, Weber Chiliad, Young KJ, Yu H. Côté P, et al. Chiropr Man Therap. 2021 Mar 8;29(1):eleven. doi: x.1186/s12998-021-00368-3. Chiropr Human being Therap. 2021. PMID: 33685457 Free PMC commodity. No abstract available.

Abstract

Background: A small proportion of chiropractors, osteopaths, and other transmission medicine providers use spinal manipulative therapy (SMT) to manage non-musculoskeletal disorders. Nevertheless, the efficacy and effectiveness of these interventions to prevent or care for non-musculoskeletal disorders remain controversial.

Objectives: We convened a Global Summit of international scientists to comport a systematic review of the literature to determine the efficacy and effectiveness of SMT for the primary, secondary and third prevention of non-musculoskeletal disorders.

Global summit: The Global Height took identify on September fourteen-15, 2019 in Toronto, Canada. It was attended by fifty researchers from 8 countries and 28 observers from 18 chiropractic organizations. At the tiptop, participants critically appraised the literature and synthesized the evidence.

Systematic review of the literature: We searched MEDLINE, Embase, the Cochrane Central Annals of Controlled Trials, the Cumulative Index to Nursing and Allied Health, and the Index to Chiropractic Literature from inception to May 15, 2019 using subject area headings specific to each database and complimentary text words relevant to manipulation/manual therapy, effectiveness, prevention, treatment, and not-musculoskeletal disorders. Eligible for review were randomized controlled trials published in English language. The methodological quality of eligible studies was assessed independently past reviewers using the Scottish Intercollegiate Guidelines Network (SIGN) criteria for randomized controlled trials. We synthesized the testify from manufactures with loftier or acceptable methodological quality according to the Synthesis without Meta-Analysis (SWiM) Guideline. The final risk of bias and evidence tables were reviewed past researchers who attended the Global Summit and 75% (38/50) had to approve the content to reach consensus.

Results: Nosotros retrieved 4997 citations, removed 1123 duplicates and screened 3874 citations. Of those, the eligibility of 32 articles was evaluated at the Global Summit and xvi manufactures were included in our systematic review. Our synthesis included half-dozen randomized controlled trials with acceptable or high methodological quality (reported in seven manufactures). These trials investigated the efficacy or effectiveness of SMT for the direction of infantile colic, childhood asthma, hypertension, primary dysmenorrhea, and migraine. None of the trials evaluated the effectiveness of SMT in preventing the occurrence of non-musculoskeletal disorders. Consensus was reached on the content of all risk of bias and testify tables. All randomized controlled trials with loftier or acceptable quality found that SMT was not superior to sham interventions for the handling of these not-musculoskeletal disorders. Six of 50 participants (12%) in the Global Meridian did not approve the terminal report.

Conclusion: Our systematic review included six randomized clinical trials (534 participants) of acceptable or loftier quality investigating the efficacy or effectiveness of SMT for the treatment of not-musculoskeletal disorders. We found no evidence of an effect of SMT for the management of non-musculoskeletal disorders including infantile colic, childhood asthma, hypertension, master dysmenorrhea, and migraine. This finding challenges the validity of the theory that treating spinal dysfunctions with SMT has a physiological effect on organs and their role. Governments, payers, regulators, educators, and clinicians should consider this evidence when developing policies about the employ and reimbursement of SMT for non-musculoskeletal disorders.

Keywords: Chiropractic; Effectiveness; Efficacy; Mobilization; Non-musculoskeletal; Spinal manipulation; Systematic review.

Disharmonize of involvement argument

The following individuals had cipher to declare: CA, IA, JB, DDC, JDC, AE, RE, GG, CAH, MH, SI, AK, AAM, ALM, DN, ADR, HS, MS, AV, JJW.

MA Blanchette reports research grants unrelated to this work from University of Quebec-Trois-Rivieres; fees medical-legal expertise from the Canadian Chiropractic Protective Association and Intact Assurance. A Bussières is an Editorial Lath fellow member of Chiropractic & Transmission Therapies just had no part in the editorial or peer-review process. He reports receiving grants unrelated to this piece of work from the Canadian Chiropractic Research Foundation. C Cancelliere is funded by the Canadian Chiropractic Research Foundation. HW Christensen has received grants unrelated to this work from The Danish Chiropractic Inquiry Fund and my institution has paid for accommodation and travel expenses. P Côté reports research grants unrelated to this piece of work from Aviva Canada, Canadian Institutes of Health Inquiry-Canada Enquiry Chair Program, Canadian Chiropractic Association, Canadian Chiropractic Research Foundation, College of Chiropractors of British Columbia, Et liv i bevegelse" (ELIB), French Chiropractic Clan, Financial Services Commission of Ontario, Ontario Ministry of Finance, Ontario Trillium Foundation; travel expenditures unrelated to this piece of work from Griffith University - Whiplash Symposium 2017, Eurospine, Southern Denmark University, Institut Franco-Europeen de Chiropraxie, Karolinska Institutet, North American Spine Lodge, University of Quebec-Trois-Rivieres, University of Zurich, World Federation of Chiropractic; fees for medical-legal expertise from the Canadian Chiropractic Protective Association. K Deluca reports she has multiple research grants from Australian funding agencies, unrelated to this work. She has received coverage of travel expenditures associated with the Global Height. SD French is a Deputy Editor-in-Principal of Chiropractic & Manual Therapies just had no part in the editorial or peer-review process of this manuscript. He has received research grants unrelated to this work from Australian and international funding agencies and from chiropractic professional associations. J Hartvigsen reports that he holds multiple research grants from Danish and international funding agencies and charities. He has received coverage of travel expenditures from multiple sources internationally in connection with speaking engagements. Inside the past yr he has received speaking fees from Parker Seminars and Novartis. J Hébert receives salary support from the Canadian Chiropractic Research Foundation and the New Brunswick Wellness Research Foundation. He is besides an Acquaintance Editor of Chiropractic and Transmission Therapies but played no part in the review of this submission and was blinded to the process. G Kawchuk reports active enquiry grants unrelated to this work from The Natural Sciences and Engineering science Inquiry, The National Institutes of Health, The Alberta Spine Foundation, The American Orthotic and Prosthetic Association, The New Frontiers in Research Fund and the Canadian Chiropractic Research Foundation. Travel expenditures unrelated to this work in the past year include Kiropraktik i Sverige Live, Et liv i bevegelse" (ELIB), the Nordic Institute of Chiropractic and Clinical Biomechanics, The American Chiropractic Clan, The National Institutes of Health, The British Columbia Chiropractic Association, and The World Federation of Chiropractic. Fees for medical-legal expertise unrelated to this work from the Canadian Chiropractic Protective Association. HH Lauridsen holds multiple research grants from funding agencies and charities of which the principal contributor is the Danish Foundation for Chiropractic Enquiry and Postgraduate Instruction. HHL is soon employed as associate professor and head of chiropractic studies at University of Southern Denmark. No funding has been received for the present project. C Leboeuf-Yde reports no competing interests as she obtains no funding from the chiropractic profession. S Mior reports receiving grants unrelated to this piece of work from the Canadian Chiropractic Association, Ontario Chiropractic Association, and Canadian Chiropractic Research Foundation. S O'Neill reports funding by local, regional wellness government and by the Danish chiropractic foundation for research and postgraduate pedagogy, only not in relation specifically to this project I Pagé has received grants unrelated to this piece of work. S Perle is an Acquaintance Editor of Chiropractic & Manual Therapies but had no part in the editorial or peer-review process. He has received grants unrelated to this work from the West Hartford Group, Inc. and NCMIC Foundation, Inc. E Poulsen reports enquiry grants from the Danish Foundation for Chiropractic Inquiry and Postgraduate Education, which is funded by the Danish chiropractors, and the Danish Regions. No funding has been received for the present project. J Quon has funding unrelated to this work from the Canadian Chiropractic Guideline Initiative and The Vancouver Foundation. He is a member of the editorial board of Chiropractic & Transmission Therapies just had no part in the editorial or peer-review procedure for this manuscript. Yard Rezai is a member of the World Federation of Chiropractic Research Disability and Rehabilitation Committee. JS is am active licensed member of Ontario and Canadian Chiropractic Associations. He is currently receiving enquiry support from the Ontario Chiropractic Clan. Previously received research support from Canadian Chiropractic Research Foundation and Ontario Chiropractic Clan. Thou Young man holds research grants unrelated to this work. He received the Chiropractic Australia Inquiry Foundation Travel Grant 2019 to embrace travel expenses associated with the Global Summit. Within the by year he has received consultation fees unrelated to this work. He is a not-executive director of Chiropractic Australia. He is a governor of the Sydney Higher of Chiropractic. M Weber was supported by grants from the National Institute of Neurological Disorders and Stroke (K23NS104211 and L30NS108301) of the National Institutes of Health (Bethesda, Maryland, United states of america). The content is solely the responsibleness of the authors and does not necessarily represent the official views of the National Institutes of Health. Thou J Young received a Personal PhD Grant (2018) from the Royal Higher of Chiropractors (UK - £1600) that partially funded two papers unrelated to this work.

Figures

Fig. i

PRISMA Flow diagram

Comment in

• Response to Lawrence DJ: the global summit on the efficacy and effectiveness of spinal manipulative therapy for the prevention and handling of not-musculoskeletal disorders: a systematic review of the literature.

  Côté P, Hartvigsen J, Axén I, Leboeuf-Yde C, Corso M, Shearer H, Wong J, Marchand AA, Cassidy JD, French S, Kawchuk GN, Mior S, Poulsen East, Srbely J, Ammendolia C, Blanchette MA, Busse JW, Bussières A, Cancelliere C, Christensen HW, De Carvalho D, De Luca K, Rose AD, Eklund A, Engel R, Goncalves Thousand, Hebert J, Hincapié CA, Hondras M, Kimpton A, Lauridsen HH, Innes S, Meyer AL, Newell D, O'Neill S, Pagé I, Passmore S, Perle SM, Quon J, Rezai Grand, Stupar M, Swain Thousand, Vitiello A, Weber K, Young KJ, Yu H. Côté P, et al. Chiropr Man Therap. 2021 Jul twenty;29(1):26. doi: ten.1186/s12998-021-00380-7. Chiropr Homo Therap. 2021. PMID: 34284791 Free PMC article. No abstruse available.

Similar articles

• Extrapolating Across the Data in a Systematic Review of Spinal Manipulation for Nonmusculoskeletal Disorders: A Fall From the Elevation.

  Goertz CM, Hurwitz EL, Murphy BA, Coulter ID. Goertz CM, et al. J Manipulative Physiol Ther. 2021 May;44(4):271-279. doi: ten.1016/j.jmpt.2021.02.003. Epub 2021 Apr 18. J Manipulative Physiol Ther. 2021. PMID: 33879350

• Assessment of Studies Evaluating Spinal Manipulative Therapy and Infectious disease and Immune System Outcomes: A Systematic Review.

  Chow Due north, Hogg-Johnson S, Mior S, Cancelliere C, Injeyan S, Teodorczyk-Injeyan J, Cassidy JD, Taylor-Vaisey A, Côté P. Chow North, et al. JAMA Netw Open up. 2021 Apr 1;four(4):e215493. doi: 10.1001/jamanetworkopen.2021.5493. JAMA Netw Open. 2021. PMID: 33847753 Gratis PMC article.

• Spinal manipulative therapy for acute low-dorsum pain.

  Rubinstein SM, Terwee CB, Assendelft WJ, de Boer MR, van Tulder MW. Rubinstein SM, et al. Cochrane Database Syst Rev. 2012 Sep 12;2012(9):CD008880. doi: 10.1002/14651858.CD008880.pub2. Cochrane Database Syst Rev. 2012. PMID: 22972127 Gratis PMC article. Review.

• Benefits and harms of spinal manipulative therapy for the treatment of chronic depression back hurting: systematic review and meta-analysis of randomised controlled trials.

  Rubinstein SM, de Zoete A, van Middelkoop M, Assendelft WJJ, de Boer MR, van Tulder MW. Rubinstein SM, et al. BMJ. 2019 Mar xiii;364:l689. doi: 10.1136/bmj.l689. BMJ. 2019. PMID: 30867144 Free PMC article.

• Efficacy of spinal manipulation and mobilization for low back pain and cervix pain: a systematic review and best evidence synthesis.

  Bronfort M, Haas M, Evans RL, Bouter LM. Bronfort M, et al. Spine J. 2004 May-Jun;4(3):335-56. doi: x.1016/j.spinee.2003.06.002. Spine J. 2004. PMID: 15125860 Review.

Cited past 9 manufactures

• Digging deeper: exploring chiropractors online claims almost non-musculoskeletal disorders.

  O'Neill Southward, Wahlqvist AB, Simonsen NK, Myburgh C, Jensen RK. O'Neill South, et al. Chiropr Human Therap. 2021 Dec 6;29(1):50. doi: 10.1186/s12998-021-00407-z. Chiropr Man Therap. 2021. PMID: 34872561 Free PMC article.

• The importance of selecting the correct site to apply spinal manipulation when treating spinal pain: Myth or reality? A systematic review.

  Nim CG, Downie A, O'Neill Due south, Kawchuk GN, Perle SM, Leboeuf-Yde C. Nim CG, et al. Sci Rep. 2021 Dec 3;eleven(1):23415. doi: 10.1038/s41598-021-02882-z. Sci Rep. 2021. PMID: 34862434 Free PMC article.

• Smoke Screen to Distract From Flawed Science: A Response to Côté et al. Over Criticisms to Their Scarce 'Rapid Review' on Chiropractic 10-Ray Utility.

  Oakley PA, Betz JW, Harrison DE, Siskin LA, Hirsh DW; International Chiropractors Clan Rapid Response Inquiry Review Subcommittee. Oakley PA, et al. Dose Response. 2021 Nov xx;19(four):15593258211058341. doi: x.1177/15593258211058341. eCollection 2021 October-Dec. Dose Response. 2021. PMID: 34819817 Free PMC article. No abstract available.

• Reconciling evidence and feel in the context of prove-based practice.

  Alexopulos S, Cancelliere C, Côté P, Mior S. Alexopulos South, et al. J Can Chiropr Assoc. 2021 Aug;65(2):132-136. J Tin can Chiropr Assoc. 2021. PMID: 34658385 Free PMC article. No abstruse bachelor.

• The association between chiropractors' view of exercise and patient encounter-level characteristics in Ontario, Canada: a cross-sectional study.

  Wong JJ, Hogg-Johnson S, Bussières AE, French SD, Mior SA. Wong JJ, et al. Chiropr Man Therap. 2021 Sep 28;29(one):41. doi: x.1186/s12998-021-00398-x. Chiropr Man Therap. 2021. PMID: 34583730 Gratis PMC commodity.

References

1. 1. Côté P, Wong JJ, Sutton D, Shearer HM, Mior South, Randhawa K, et al. Management of neck pain and associated disorders: a clinical exercise guideline from the Ontario protocol for traffic injury direction (OPTIMa) collaboration. Eur Spine J. 2016;25(7):2000–2022. doi: ten.1007/s00586-016-4467-7. - DOI - PubMed
2. 1. Côté P, Yu H, Shearer HM, Randhawa Thousand, Wong JJ, Mior South, et al. Non-pharmacological management of persistent headaches associated with neck pain: A clinical practice guideline from the Ontario protocol for traffic injury management (OPTIMa) collaboration. Eur J Hurting. 2019;1051–70. - PubMed
3. 1. Wong J, Côté P, Sutton D, Randhawa Chiliad, Yu H, Varatharajan S, et al. Clinical practice guidelines for the noninvasive management of low back pain: a systematic review by the Ontario protocol for traffic injury management (OPTIMa) collaboration. Eur J Pain. 2017;21(two):201–216. doi: 10.1002/ejp.931. - DOI - PubMed
4. 1. Kjaer P, Kongsted A, Hartvigsen J, Isenberg-Jorgensen A, Schiottz-Christensen B, Soborg B, et al. National clinical guidelines for non-surgical treatment of patients with recent onset neck hurting or cervical radiculopathy. Eur Spine J. 2017;26(9):2242–2257. doi: ten.1007/s00586-017-5121-eight. - DOI - PubMed
5. 1. Stochkendahl MJ, Kjaer P, Hartvigsen J, Kongsted A, Aaboe J, Andersen M, et al. National Clinical Guidelines for non-surgical handling of patients with recent onset depression dorsum pain or lumbar radiculopathy. Eur Spine J. 2018;27(1):60–75. doi: 10.1007/s00586-017-5099-2. - DOI - PubMed

Publication types

MeSH terms

LinkOut - more resource

• Total Text Sources

  • BioMed Primal
  • Europe PubMed Cardinal
  • PubMed Fundamental

• Other Literature Sources

  • scite Smart Citations

• Medical

  • MedlinePlus Consumer Health Data
  • MedlinePlus Health Information

• Research Materials

  • NCI CPTC Antibody Characterization Program

wootonsirle1977.blogspot.com

Source: https://pubmed.ncbi.nlm.nih.gov/33596925/

Share this post